The Greatest Guide To akorn promethazine codeine
The Greatest Guide To akorn promethazine codeine
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If the reaction to an opioid antagonist is suboptimal or only brief in character, administer extra antagonist as directed with the product or service’s prescribing information and facts. The respiratory depressant outcomes of promethazine aren't reversed by opioid antagonists, like naloxone.
g., amiodarone, quinidine) could lead to an increase in codeine plasma concentrations as well as a lessen in active metabolite morphine plasma concentration which could cause an analgesic efficacy reduction or signs or symptoms of opioid withdrawal.
5.17 Bone-Marrow Depression Promethazine HCl and codeine phosphate oral Resolution should be employed with caution in people with bone-marrow melancholy. Leukopenia and agranulocytosis are noted, generally when promethazine continues to be Utilized in Affiliation with other recognised marrow-poisonous brokers.
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Make contact with local point out professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this products.
Since recurrences of NMS have already been documented with phenothiazines, prevent utilization of promethazine HCl and codeine phosphate oral Answer in individuals using a background in step with NMS.
INDICATIONS AND Use Promethazine HCl and codeine phosphate oral Alternative is a mix of codeine, an opioid agonist, and promethazine, a phenothiazine, indicated for that more info temporary aid of cough and higher respiratory indications associated with allergy or perhaps the prevalent cold in sufferers eighteen decades of age and older. (one) (1)
If concomitant use is warranted, meticulously notice the affected individual, notably all through procedure initiation. Discontinue promethazine HCl and codeine phosphate oral solution if serotonin syndrome is suspected.
There aren't any details on the existence of promethazine HCl and codeine phosphate oral Resolution in human milk, the results of promethazine HCl and codeine phosphate oral Resolution about the breastfed infant, or the consequences of promethazine HCl and codeine phosphate oral Option on milk generation; having said that, data are offered with codeine and promethazine.
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Lactation At least a single Demise was noted in a very nursing toddler who was subjected to large amounts of morphine in breast milk because the mom was an extremely-swift metabolizer of codeine.
It is soluble in water and freely soluble in Liquor. The molecular body weight is 320.88. Its molecular components is C17H20N2S•HCl, and it's got the subsequent chemical composition.
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